SIRT-IN-1

• UNSPSC Description:

  SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

• Target Antigen:

  Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease; Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/SIRT-IN-1.html

• Solubility:

  DMSO : 19.23 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  NC(C1=CC2=NC=NC(N3CCC(CCNC(C(C)(C)C)=O)CC3)=C2S1)=O

• Molecular Weight:

  389.52

• References & Citations:

  [1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1431411-60-7