SIRT-IN-5

• UNSPSC Description:

  SIRT-IN-5 is a SIRT3 inhibitor, with an IC50 value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ[1].

• Target Antigen:

  Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sirt-in-5.html

• Smiles:

  O=C(N1CCN(CC1)C2=CC=CC=C2F)C3=CC(C4=CC=C(C=C4)N5C=CN=C5)=NC6=CC=C(C)C=C63

• Molecular Weight:

  491.56

• References & Citations:

  [1]Du Y, et al. Structural modification of 2-phenylquinoline-4-carboxylic acid containing SIRT3 inhibitors for the cancer differentiation therapy. Chem Biol Drug Des. 2024 Aug;104(2):e14595.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported