c-Met-IN-24

• UNSPSC Description:

  c-Met-IN-24 (compound 3g) is a dual-target inhibitor of STAT-3 ([1]=4.7 μM) and c-MET ([1]=12.67 μM) with anticancer activity. c-Met-IN-24 arrests the G2/M cell cycle and induces apoptosis in SNB-75 cells. c-Met-IN-24 can be used in the study of central nervous system cancers[1].

• Target Antigen:

  Apoptosis; c-Met/HGFR; STAT

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c-met-in-24.html

• Smiles:

  COC1=CC=CC2=C1OC(C(C3=CSC(NNC(NC4=CC=C(Cl)C=C4)=O)=N3)=C2)=O

• Molecular Weight:

  442.88

• References & Citations:

  [1]Naguib, et al. "Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents." Bioorganic Chemistry (2024): 107682.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported