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C-Met-IN-24

CAT: 0804-HY-162803Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162803Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-Met-IN-24 (compound 3g) is a dual-target inhibitor of STAT-3 ([1]=4.7 μM) and c-MET ([1]=12.67 μM) with anticancer activity. c-Met-IN-24 arrests the G2/M cell cycle and induces apoptosis in SNB-75 cells. c-Met-IN-24 can be used in the study of central nervous system cancers[1].
UNSPSC
12352211
Target
Apoptosis; c-Met/HGFR; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-24.html
Smiles
COC1=CC=CC2=C1OC(C(C3=CSC(NNC(NC4=CC=C(Cl)C=C4)=O)=N3)=C2)=O
Molecular Formula
C20H15ClN4O4S
Molecular Weight
442.88
References & Citations
[1]Naguib, et al. "Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents." Bioorganic Chemistry (2024) : 107682.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Met; STAT3

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