c-Met-IN-10

• CAS Number:

  2415291-03-9

• UNSPSC Description:

  c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].

• Target Antigen:

  Apoptosis; c-Met/HGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c-met-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=NN(C(N(C1=O)C)=O)C2=CC=CC=C2)NC3=CC=C(C(F)=C3)OC4=CC(NC(C5CC5)=O)=NC=C4

• Molecular Weight:

  516.48

• References & Citations:

  [1]Liu J, et al. Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors. Eur J Med Chem. 2020;194:112244.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported