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C-Met-IN-10

CAT: 0804-HY-146274Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146274Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].
CAS Number
2415291-03-9
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NN(C(N(C1=O)C)=O)C2=CC=CC=C2)NC3=CC=C(C(F)=C3)OC4=CC(NC(C5CC5)=O)=NC=C4
Molecular Formula
C26H21FN6O5
Molecular Weight
516.48
References & Citations
[1]Liu J, et al. Design, synthesis and biological evaluation of novel N-[4- (2-fluorophenoxy) pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors. Eur J Med Chem. 2020;194:112244.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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