EHop-016

CAT: 0804-HY-12810-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12810-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor. EHop-016 inhibits Rac1 activity with an IC50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration[1][2].
CAS Number
[1380432-32-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EHop-016.html
Purity
99.85
Solubility
DMSO : ≥ 32 mg/mL
Smiles
CCN1C2=C(C3=C1C=CC=C3)C=C(NC4=NC(NCCCN5CCOCC5)=NC=C4)C=C2
Molecular Formula
C25H30N6O
Molecular Weight
430.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Montalvo-Ortiz BL, et al. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem. 2012 Apr 13;287 (16) :13228-38.|[2]Castillo-Pichardo L, et al. The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model. Transl Oncol. 2014 Oct 24;7 (5) :546-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS3601575-01EHop-016
A12740-10EHop-016 10mg
A12740-5EHop-016 5mg
A12740-50EHop-016 50mg
A12740-25EHop-016 25mg
A12740-100EHop-016 100mg
A12740-200EHop-016 200mg
A12740-500EHop-016 500mg
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6248/5EHop 016 5 mg

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