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MSDC 0160

CAT: 0804-HY-100550-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100550-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT) -modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC) . MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease[1][2].
CAS Number
146062-49-9
Product Name Alternative
Mitoglitazone; CAY10415
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Insulin Receptor; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MSDC_0160.html
Purity
99.37
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(N1)SC(CC2=CC=C(OCC(C3=NC=C(CC)C=C3)=O)C=C2)C1=O
Molecular Formula
C19H18N2O4S
Molecular Weight
370.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Rohatgi N, et al. Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS One. 2013 May 1;8 (5) :e62012.|[2]Ghosh A, et al. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration inexperimental models of Parkinson's disease. Sci Transl Med. 2016 Dec 7;8 (368) :368ra174.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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A14294-1MSDC-0160 1mg
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