CLB-016

• UNSPSC Description:

  CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC50 of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response[1].

• Target Antigen:

  HIF/HIF Prolyl-Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/clb-016.html

• Smiles:

  O=C(C1=NN(CC)C=C1NC(C2=CC=C(CN3N=C(C)C=C3C)O2)=O)N

• Molecular Weight:

  356.38

• References & Citations:

  [1]Yasuda Y, et al. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Bioorg Med Chem. 2015 Apr 15;23(8):1776-87.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1005636-29-2