CLB-016

• Description :

  CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC50 of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response[1].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/clb-016.html

• Smiles :

  O=C(C1=NN(CC)C=C1NC(C2=CC=C(CN3N=C(C)C=C3C)O2)=O)N

• Molecular Formula :

  C17H20N6O3

• Molecular Weight :

  356.38

• References & Citations :

  [1]Yasuda Y, et al. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF) -1 inhibitors. Bioorg Med Chem. 2015 Apr 15;23 (8) :1776-87.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1005636-29-2]