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USP5-IN-1

CAT: 0804-HY-139979-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139979-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM) . USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
CAS Number
2851040-81-6
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/usp5-in-1.html
Purity
99.73
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C(NCC(O)=O)=O)N=C1)(N2CCC(C3=CC=C(Cl)C=C3)CC2)=O
Molecular Formula
C19H20ClN3O5S
Molecular Weight
437.90
References & Citations
[1]Mann MK, et al. Structure-Activity Relationship of USP5 Inhibitors [published correction appears in J Med Chem. 2022 Jan 13;65 (1) :889]. J Med Chem. 2021;64 (20) :15017-15036.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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