USP5, Human (His)

• Description:

  USP5 protein selectively cleaves branched multiubiquitin polymers, favoring 'Lys-48'-linked polyubiquitin disassembly. It exhibits lower affinity for linear and 'Lys-63'-linked polyubiquitin. USP5 knockdown leads to p53/TP53 accumulation, enhancing p53/TP53 transcriptional activity, as unanchored polyubiquitin competes with ubiquitinated p53/TP53 for proteasomal recognition, unlike MDM2. USP5 Protein, Human (His) is the recombinant human-derived USP5 protein, expressed by E. coli, with N-His labeled tag.

• Product Name Alternative:

  USP5 Protein, Human (His), Human, E. coli

• UNSPSC:

  12352202

• Type:

  Reference compound

• Assay Protocol:

  https://www.medchemexpress.com/cytokines/usp5-protein-human-his.html

• Smiles:

  AELSEEALLS VLPTIRVPKA GDRVHKDECA FSFDTPESEG GLYICMNTFL GFGKQYVERH FNKTGQRVYL HLRRTRRPKE EDPATGTGDP PRKKPTRLAI GVEGGFDLSE EKFELDEDVK IVILPDYLEI ARDGLGGLPD IVRDRVTSAV EALLSADSAS RKQEVQAWDG EVRQVSKHAF SLKQLDNPAR IPPCGWKCSK CDMRENLWLN LTDGSILCGR RYFDGSGGNN HAVEHYRETG YPLAVKLGTI TPDGADVYSY DEDDMVLDPS LAEHLSHFGI DMLKMQKTDK TMTELEIDMN QRIGEWELIQ ESGVPLKPLF GPGYTGIRNL GNSCYLNSVV QVLFSIPDFQ RKYVDKLEKI FQNAPTDPTQ DFSTQVAKLG HGLLSGEYSK PVPESGDGER VPEQKEVQDG IAPRMFKALI GKGHPEFSTN RQQDAQEFFL HLINMVERNC RSSENPNEVF RFLVEEKIKC LATEKVKYTQ RVDYIMQLPV PMDAALNKEE LLEYEEKKRQ AEEEKMALPE LVRAQVPFSS CLEAYGAPEQ VDDFWSTALQ AKSVAVKTTR FASFPDYLVI QIKKFTFGLD WVPKKLDVSI EMPEELDISQ LRGTGLQPGE EELPDIAPPL VTPDEPKGSL GFYGNEDEDS FCSPHFSSPT SPMLDESVII QLVEMGFPMD ACRKAVYYTG NSGAEAAMNW VMSHMDDPDF ANPLILPGSS GPGSTSAAAD PPPEDCVTTI VSMGFSRDQA LKALRATNNS LERAVDWIFS HIDDLDAEAA MDISEGRSAA DSISESVPVG PKVRDGPGKY QLFAFISHMG TSTMCGHYVC HIKKEGRWVI YNDQKVCASE KPPKDLGYIY FYQRVAS

• Molecular Formula:

  8078 (Gene_ID) P45974-1 (A2-S858) (Accession)

• Molecular Weight:

  Approximately 97.8 kDa

• Shipping Conditions:

  Dry ice.

• Scientific Category:

  Recombinant Proteins