M1145 (TFA)

• UNSPSC Description:

  M1145 TFA, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 TFA shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 TFA has an additive effect on the signal transduction of galanin[1].

• Target Antigen:

  Neuropeptide Y Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/m1145-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C(F)(F)F)=O.O=C([C@H]1N(CCC1)C([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H](CC(N)=O)NC(CNC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O

• Molecular Weight:

  2774.23 (free base)

• References & Citations:

  [1]Runesson J, Saar I, Lundström L, Järv J, Langel U. A novel GalR2-specific peptide agonist. Neuropeptides. 2009;43(3):187-192.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported