M1145

• UNSPSC Description:

  M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].

• Target Antigen:

  Neuropeptide Y Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/m1145.html

• Purity:

  99.54

• Solubility:

  H2O : ≥ 50 mg/mL

• Smiles:

  C(=O)(N1[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)C)=O)CCC2)CCC1)[C@H]3N(C([C@@H](NC([C@@H](NC(=O)[C@H]4N(C(CNC([C@@H](NC([C@@H](NC([C@H](CC5=CC=C(O)C=C5)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=6C=7C(NC6)=CC=CC7)NC([C@@H](NC(CNC([C@@H](NC(CNC([C@H](CCCNC(=N)N)N)=O)=O)CCCNC(=N)N)=O)=O)CC(N)=O)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)CC(N)=O)=O)CO)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CCC4)[C@H](C)C)=O)CC(C)C)=O)CCC3

• Molecular Weight:

  2774.23

• References & Citations:

  [1]Runesson J, Saar I, Lundström L, Järv J, Langel U. A novel GalR2-specific peptide agonist. Neuropeptides. 2009;43(3):187-192.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  1172089-00-7