LYP-8

• Description :

  LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro (Sturcture Note: (Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801); Pink: Nampt inhibitor Nampt-IN-11 (HY-158689) ) [1].

• UNSPSC :

  12352005

• Target :

  NAMPT; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lyp-8.html

• Purity :

  99.89

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C4=CC=C(C=C4)C(N5CCC(CC5)CCCCNC(/C=C/C6=CN=CC=C6)=O)=O)=O)=O)=O)O)=O)C

• Molecular Formula :

  C56H74N8O10S

• Molecular Weight :

  1051.30

• References & Citations :

  [1]Lu T, et al. Design of FK866-Based Degraders for Blocking the Nonenzymatic Functions of Nicotinamide Phosphoribosyltransferase. J Med Chem. 2024;67 (10) :8099-8121.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported