LYP-8

• UNSPSC Description:

  LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801)；Pink: Nampt inhibitor Nampt-IN-11 (HY-158689))[1].

• Target Antigen:

  NAMPT; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lyp-8.html

• Smiles:

  CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C4=CC=C(C=C4)C(N5CCC(CC5)CCCCNC(/C=C/C6=CN=CC=C6)=O)=O)=O)=O)=O)O)=O)C

• Molecular Weight:

  1051.30

• References & Citations:

  [1]Lu T, et al. Design of FK866-Based Degraders for Blocking the Nonenzymatic Functions of Nicotinamide Phosphoribosyltransferase. J Med Chem. 2024;67(10):8099-8121.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported