LYP-IN-3

• Target:

  Phosphatase

• Related Pathways:

  Metabolism

• Bioactivity:

  LYP-IN-3 (compound D34) is a selective Lymphoid-tyrosine phosphatase (LYP) inhibitor (Ki=0.93 ?M) that modulates the T-cell receptor (TCR) signaling pathway during tumor progression. It promotes T-cell activation, hinders M2 macrophage polarization, and increases PD-1/PD-L1 expression. When combined with PD-1/PD-L1 inhibitors, LYP-IN-3 may enhance cancer immunotherapy [1].

• Molecular Formula:

  C35H27NO6S

• Molecular Weight:

  589.66

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C