LYP-IN-1

LYP-IN-1

• CAS Number: 1404436-51-6
• UNSPSC Description: LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) and SHP2 (IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders[1]. LYP-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Phosphatase; SHP2
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/lyp-in-1.html
• Purity: 99.78
• Solubility: DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=C(O)C=C(OC(C2=CC=C(OCC(NC3CC3)=O)C=C2)=C4C#CC5=CC=CC(Cl)=C5)C4=C1)O
• Molecular Weight: 501.91
• References & Citations: [1]A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated With Autoimmune Diseases
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported