(E/Z) -GO289

• Description:

  (E/Z) -GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM) . (E/Z) -GO289 strongly lengthens circadian period. (E/Z) -GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

• Product Name Alternative:

  CP 526555

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Casein Kinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e-z-go289.html

• Concentration:

  10mM

• Purity:

  98.98

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  OC1=CC(Br)=C(/C=N/N2C(SC)=NN=C2C3=CC=CC=C3)C=C1OC

• Molecular Formula:

  C17H15BrN4O2S

• Molecular Weight:

  419.30

• Precautions:

  H315, H319

• References & Citations:

  [1]Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5 (1) :eaau9060. Published 2019 Jan 23.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [694522-87-7]