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(E/Z) -GO289

CAT: 0804-HY-115519-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115519-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E/Z) -GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM) . (E/Z) -GO289 strongly lengthens circadian period. (E/Z) -GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function[1].
CAS Number
694522-87-7
Product Name Alternative
CP 526555
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-go289.html
Concentration
10mM
Purity
98.98
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC(Br)=C(/C=N/N2C(SC)=NN=C2C3=CC=CC=C3)C=C1OC
Molecular Formula
C17H15BrN4O2S
Molecular Weight
419.30
Precautions
H315, H319
References & Citations
[1]Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5 (1) :eaau9060. Published 2019 Jan 23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported