(E/Z) -GO289

• Description :

  (E/Z) -GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM) . (E/Z) -GO289 strongly lengthens circadian period. (E/Z) -GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

• CAS Number :

  [694522-87-7]

• Product Name Alternative :

  CP 526555

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  Casein Kinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e-z-go289.html

• Concentration :

  10mM

• Purity :

  98.98

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC1=CC(Br)=C(/C=N/N2C(SC)=NN=C2C3=CC=CC=C3)C=C1OC

• Molecular Formula :

  C17H15BrN4O2S

• Molecular Weight :

  419.30

• Precautions :

  H315, H319

• References & Citations :

  [1]Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5 (1) :eaau9060. Published 2019 Jan 23.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported