MK 0893

• Description :

  MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.

• UNSPSC :

  12352005

• Target :

  GCGR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/mk-0893.html

• Purity :

  99.83

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC(C2=NN(C(C3=CC4=C(C=C3)C=C(OC)C=C4)=C2)[C@H](C5=CC=C(C=C5)C(NCCC(O)=O)=O)C)=CC(Cl)=C1

• Molecular Formula :

  C32H27Cl2N3O4

• Molecular Weight :

  588.48

• References & Citations :

  [1]Xiong Y, et al. Discovery of a novel glucagon receptor antagonist N-[ (4-{ (1S) -1-[3- (3, 5-dichlorophenyl) -5- (6-methoxynaphthalen-2-yl) -1H-pyrazol-1-yl]ethyl}phenyl) carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.J Med Chem. 2012 Jul 12

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [870823-12-4]