PEN2 rabbit pAb

PEN2 rabbit pAb

• Description: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
• Gene ID: 55851
• UniProt: Q9NZ42
• Cellular Locus: Endoplasmic reticulum membrane ; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein. Membrane ; Multi-pass membrane protein. Predominantly located in the endoplasmic reticulum and in the cis-Golgi..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human PEN2 AA range: 51-101
• Clonality: Polyclonal
• Validated Applications: IHC, IF
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p 1：50-200
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.