PEN2 rabbit pAb

CAT: 0855-ES14162-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES14162-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Description

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

UniProt

Q9NZ42

Swiss Prot

Q9NZ42

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human PEN2 AA range: 51-101

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF

Concentration

1 mg/ml

Dilution

IHC-p 1: 50-200

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Predominantly located in the endoplasmic reticulum and in the cis-Golgi. .

Gene ID (Human)

55851

UniProtKB · Q9NZ42

Gamma-secretase subunit PEN-2

PEN2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9NZ42
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PSENEN
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B2R5L9

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneEndoplasmic reticulumGolgi apparatusMembrane

Biological process

Notch signaling pathway

Domain

TransmembraneTransmembrane helix

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Alternative Products

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UB-GEN-10820	PEN2 rabbit pAb
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JOT-AP11874-01	PEN2 Rabbit Polyclonal Antibody
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