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Streptococcus pyogenes IdeS Protein

CAT: 0013-GTR18877786-01Size: 25000 UDry Ice: NoHazardous: No
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CAT#:0013-GTR18877786-01Size:25000 U
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IdeS from Streptococcus pyogenes, also known as Mac-1, is an endopeptidase with specificity for IgG. The bacterial protein Mac-1 adopts an alpha/beta fold, with 14 beta strands and 9 alpha helices. The N-terminal domain is made up predominantly of alpha helices, whereas the C-terminal domain consists predominantly of beta sheets. Mac 1 blocks polymorphonuclear opsonophagocytosis, inhibits the production of reactive oxygen species and contains IgG endopeptidase activity. IdeS is a unique enzyme that digests IgG at a specific site below the hinge region, generating a homogenous pool of F (ab‘) 2 and Fc/2 fragments. IdeS digests all subclasses of human, and some classes of monkey, rabbit and sheep IgG. It has limited activity on mouse IgG2a and IgG3 - for digestion of these antibody species. IdeS is cloned from Streptococcus pyogenes and expressed in E. coli.
Reactivity
Bacteria
Conjugation
Unconjugated
Tag
N-10xHis
Form
Powder
Storage Conditions
-20°C
Notes
For research use only.

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