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(R) -SR-C-107

CAT: 0804-HY-169937Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169937Size:1 Each
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Description
(R) -SR-C-107 is an orally available inhibitor of ENL (YEAST domain-containing protein) designed to target acute myeloid leukemia (AML) . (R) -SR-C-107 targets ENL with IC50 and KD of 40 nM and 144 nM, respectively. (R) -SR-C-107 demonstrates in vivo efficacy in a xenograft mouse model of AML, with a tumor regression rate of 45% at a dose of 200 mg/kg (PO; QD) [1].
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-sr-c-107.html
Smiles
O=C(C1=CN2C(C=C1)=NN=C2)NC3=CC(NC(CN4[C@@H](C(C)C)CC4)=C5)=C5C=N3
Molecular Formula
C21H23N7O
Molecular Weight
389.45
References & Citations
[1]Guo XS, et al. Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia. J Med Chem. 2024 Nov 28;67 (22) :20100-20117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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