SH-E4A-66

• Description :

  SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide) . SH-E4A-66 is capable of coupling with EML4-ALK (EC50=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC50=2.3 μM) [1].

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK)

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sh-e4a-66.html

• Smiles :

  O=C(N1C(C=CC=C2)=C2C3=C1C=CC=C3)C4=CC(NC(C=C)=O)=CC(NC(CCl)=O)=C4

• Molecular Formula :

  C24H18ClN3O3

• Molecular Weight :

  431.87

• References & Citations :

  [1]Yang D, et al. Systematic Targeting of Protein Complexes with Molecular COUPLrs[J]. bioRxiv, 2024: 2024.07. 16.603666.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported