AMY-101 (TFA)

CAT: 0804-HY-P1717A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P1717A-01Size:1 mg
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Description
AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs) . AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].
CAS Number
[1789738-04-0]
Product Name Alternative
Cp40 (TFA)
UNSPSC
12352209
Target
Complement System; SARS-CoV
Type
Peptides
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amy-101-tfa.html
Purity
99.92
Solubility
DMSO : ≥ 50 mg/mL|H2O : ≥ 50 mg/mL
Smiles
OC(C(F)(F)F)=O.CN1C2=CC=CC=C2C(C[C@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(N(CC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N3)=O)C(C)C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](N)CC4=CC=C(C=C4)O)=O)=O)C(N(C)[C@H](C(N)=O)[C@@H](C)CC)=O)=O)CCCNC(N)=N)=O)CC5=CN=CN5)=O)C)=O)C)=O)CC6=CNC7=CC=CC=C67)=O)CC(O)=O)=O)CCC(N)=O)=O)=C1.[x]
Molecular Formula
C83H117N23O18S2.xC2HF3O2
Molecular Weight
1789.09 (free base)
References & Citations
[1]Kajikawa T, et al. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215.|[2]Mastaglio S, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Apr 29:108450.|[3]Yanyan Liu, et al. Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion. Front Immunol. 2018 Oct 22;9:2385.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Phase 2
Citation 01
BioRxiv. 2025 May 23.|Cell. 2025 May 29;188 (11) :3013-3029.e19.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Sci Total Environ. 2024 May 10:924:171681.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Virulence. 2025 Dec;16 (1) :2580104.

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