AMY-101 (TFA)

• Description :

  AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs) . AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].

• Product Name Alternative :

  Cp40 (TFA)

• UNSPSC :

  12352209

• Target :

  Complement System; SARS-CoV

• Type :

  Peptides

• Related Pathways :

  Anti-infection; Immunology/Inflammation

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/amy-101-tfa.html

• Purity :

  99.92

• Solubility :

  DMSO : ≥ 50 mg/mL|H2O : ≥ 50 mg/mL

• Smiles :

  OC(C(F)(F)F)=O.CN1C2=CC=CC=C2C(C[C@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(N(CC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N3)=O)C(C)C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](N)CC4=CC=C(C=C4)O)=O)=O)C(N(C)[C@H](C(N)=O)[C@@H](C)CC)=O)=O)CCCNC(N)=N)=O)CC5=CN=CN5)=O)C)=O)C)=O)CC6=CNC7=CC=CC=C67)=O)CC(O)=O)=O)CCC(N)=O)=O)=C1.[x]

• Molecular Formula :

  C83H117N23O18S2.xC2HF3O2

• Molecular Weight :

  1789.09 (free base)

• References & Citations :

  [1]Kajikawa T, et al. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215.|[2]Mastaglio S, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Apr 29:108450.|[3]Yanyan Liu, et al. Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion. Front Immunol. 2018 Oct 22;9:2385.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  Phase 2

• Citation 01 :

  BioRxiv. 2025 May 23.|Cell. 2025 May 29;188 (11) :3013-3029.e19.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Sci Total Environ. 2024 May 10:924:171681.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Virulence. 2025 Dec;16 (1) :2580104.

• CAS Number :

  [1789738-04-0]