AMY-101 (TFA)

• Description:

  AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs) . AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].

• Product Name Alternative:

  Cp40 (TFA)

• UNSPSC:

  12352209

• Target:

  Complement System; SARS-CoV

• Type:

  Peptides

• Related Pathways:

  Anti-infection; Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/amy-101-tfa.html

• Purity:

  99.92

• Solubility:

  DMSO : ≥ 50 mg/mL|H2O : ≥ 50 mg/mL

• Smiles:

  OC (C (F) (F) F) =O.CN1C2=CC=CC=C2C (C[C@H]3C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N (CC (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@@H] (CSSC[C@@H] (C (N[C@H] (C (N3) =O) C (C) C) =O) NC ([C@H] ([C@@H] (C) CC) NC ([C@H] (N) CC4=CC=C (C=C4) O) =O) =O) C (N (C) [C@H] (C (N) =O) [C@@H] (C) CC) =O) =O) CCCNC (N) =N) =O) CC5=CN=CN5) =O) C) =O) C) =O) CC6=CNC7=CC=CC=C67) =O) CC (O) =O) =O) CCC (N) =O) =O) =C1.[x]

• Molecular Formula:

  C83H117N23O18S2.xC2HF3O2

• Molecular Weight:

  1789.09 (free base)

• References & Citations:

  [1]Kajikawa T, et al. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215.|[2]Mastaglio S, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Apr 29:108450.|[3]Yanyan Liu, et al. Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion. Front Immunol. 2018 Oct 22;9:2385.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 2

• Citation 01:

  BioRxiv. 2025 May 23.|Cell. 2025 May 29;188 (11) :3013-3029.e19.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Sci Total Environ. 2024 May 10:924:171681.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Virulence. 2025 Dec;16 (1) :2580104.

• CAS Number:

  1789738-04-0