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LTC4S rabbit pAb

CAT: 0855-ES15085-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15085-01Size:50 µL
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Background
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Description
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008],
UniProt
Q16873
Swiss Prot
Q16873
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human LTC4S AA range: 29-79
Target
LTC4S
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus outer membrane ; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein. Nucleus membrane ; Multi-pass membrane protein.
Gene ID (Human)
4056

UniProtKB · Q16873

Leukotriene C4 synthase

LTC4S_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16873
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LTC4S
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
LTC4 synthase
EC number
4.4.1.20
Processing
—
Secondary accessions
Q8N6P0, Q9UC73, Q9UD18
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Endoplasmic reticulumMembraneNucleus

Biological process

Leukotriene biosynthesisLipid biosynthesisLipid metabolism

Molecular function

LyaseTransferase

PTM

Phosphoprotein

Domain

TransmembraneTransmembrane helix

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