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(R) -ADX-47273

CAT: 0804-HY-13058B-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13058B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
CAS Number
851881-59-9
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_R_-ADX-47273.html
Concentration
10mM
Purity
99.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@H](C2=NC(C3=CC=C(C=C3)F)=NO2)CCC1)C4=CC=C(C=C4)F
Molecular Formula
C20H17F2N3O2
Molecular Weight
369.36
References & Citations
[1]Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4 (4) :505-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5

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