ADX-47273

• Description :

  ADX-47273 is a potent, selective and brain-penetrant mGluR5 positive allosteric modulator (PAM), with an EC50 of 0.17 μM for potentiation of glutamate (50 nM) response. ADX-47273 has antipsychotic and procognitive activities[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ADX-47273.html

• Purity :

  99.94

• Solubility :

  DMSO : ≥ 31 mg/mL|Methanol : 105.5 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C1=CC=C(F)C=C1)N2C[C@@H](C3=NC(C4=CC=C(F)C=C4)=NO3)CCC2

• Molecular Formula :

  C20H17F2N3O2

• Molecular Weight :

  369.36

• Precautions :

  H301, H311, H331

• References & Citations :

  [1]Liu F, et al. ADX47273 [S- (4-fluoro-phenyl) -{3-[3- (4-fluoro-phenyl) -[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327 (3) :827-39.|[2]Xu J, et al. Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning. Learn Mem. 2013 Jul 18;20 (8) :438-45.|[3]Schlumberger C, et, al. Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia. Pharmacol Biochem Behav. 2010 Mar;95 (1) :23-30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR5

• CAS Number :

  [851881-60-2]