DB772 (hydrate)

• Description:

  DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity[1].

• Product Name Alternative:

  PF-06651600 (tosylate)

• UNSPSC:

  12352005

• Target:

  Flavivirus

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/db772-hydrate.html

• Purity:

  99.89

• Solubility:

  DMSO : ≥ 4 mg/mL

• Smiles:

  [H]Cl.C1(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)=NC5=CC=CC=C5N1.[2.8].[4].O

• Molecular Formula:

  C20H16N4O.2.8HCl.4H2O

• Molecular Weight:

  502.54

• References & Citations:

  [1]James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7 (11) :e51173.|[2]Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96 (2) :127-9.|[3]Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60 (9) :5467-82.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported