DB772

• Description :

  DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity[1].

• Product Name Alternative :

  (2R,5S)-PF-06651600, PF-06651600 (tosylate)

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Flavivirus

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/db772.html

• Purity :

  99.75

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  [H]Cl.[H]Cl.C1(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)=NC5=CC=CC=C5N1

• Molecular Formula :

  C20H18Cl2N4O

• Molecular Weight :

  401.29

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7 (11) :e51173.|[2]Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96 (2) :127-9.|[3]Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60 (9) :5467-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1451058-50-6]