VH032 thiol

• UNSPSC Description:

  VH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC[1].

• Target Antigen:

  Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-brd4-binding-moiety-3.html

• Purity:

  95.91

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)S)NC(C)=O)=O)=O)C=C2

• Molecular Weight:

  490.64

• References & Citations:

  [1]Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under argon)

• Clinical Information:

  No Development Reported

• CAS Number:

  2098836-54-3