VH032 thiol

• Description :

  VH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC[1].

• Product Name Alternative :

  VHL ligand 6

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/protac-brd4-binding-moiety-3.html

• Concentration :

  10mM

• Purity :

  95.91

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)S)NC(C)=O)=O)=O)C=C2

• Molecular Formula :

  C23H30N4O4S2

• Molecular Weight :

  490.64

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13 (5) :514-521.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under argon)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Von Hippel-Lindau (VHL)

• CAS Number :

  [2098836-54-3]