VH032-OH

• Description:

  VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vh032-oh.html

• Purity:

  99.43

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC(C=CC(C(SC=N2)=C2C)=C3)=C3O)=O)[C@H](C(C)(C)C)NC(C)=O

• Molecular Formula:

  C24H32N4O5S

• Molecular Weight:

  488.60

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8 (1) :830. Published 2017 Oct 10.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Von Hippel-Lindau (VHL)

• CAS Number:

  [2244684-42-0]