VH032-OH

• Description :

  VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/vh032-oh.html

• Purity :

  99.43

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC(C=CC(C(SC=N2)=C2C)=C3)=C3O)=O)[C@H](C(C)(C)C)NC(C)=O

• Molecular Formula :

  C24H32N4O5S

• Molecular Weight :

  488.60

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8 (1) :830. Published 2017 Oct 10.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Von Hippel-Lindau (VHL)

• CAS Number :

  [2244684-42-0]