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AS1411-C4-VH032

CAT: 0804-HY-168280Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168280Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS1411-C4-VH032 (AS1411-VH032) promotes tumor-selective degradation of MDM2, leading to tumor shrinkage without detectable toxicity[1].
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/as1411-c4-vh032.html
Smiles
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(CCCCCO['3-GGTGGTGGTGGTGTTGGTGGTGGTGG-'5])=O)=O)=O)C=C2
References & Citations
[1]Wang Z, et al. Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability. J Med Chem. 2024 Nov 14;67 (21) :18865-18882.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MDM2

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