VH032-C7-COOH

• Description :

  VH032-C7-COOH is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH032-C7-COOH contains an E3 ligase ligand and an alkyl linker with a terminal amine for conjugation of target protein ligands[1].

• CAS Number :

  [2172819-77-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  E3 Ligase Ligand-Linker Conjugates

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/vh032-c7-cooh.html

• Purity :

  99.92

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCCCCC(O)=O)=O)=O)C[C@H](O)C3

• Molecular Formula :

  C32H46N4O6S

• Molecular Weight :

  614.80

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1.2018-06-14.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported