PF-4989216

• Description:

  PF-4989216 is a potent and selective PI3Kα inhibitor with a Ki of 0.6 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Apoptosis; PI3K

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PF-4989216.html

• Concentration:

  10mM

• Purity:

  99.38

• Solubility:

  DMSO : ≥ 29 mg/mL

• Smiles:

  N#CC1=C(N2CCOCC2)SC(C3=NC=NN3)=C1C4=CC=C(C#N)C=C4F

• Molecular Formula:

  C18H13FN6OS

• Molecular Weight:

  380.40

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Liu KK, et al. Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity. ACS Med Chem Lett. 2011 Sep 19;2 (11) :809-813.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PI3Kα

• CAS Number:

  [1276553-09-3]