PF-4989216

• Description :

  PF-4989216 is a potent and selective PI3Kα inhibitor with a Ki of 0.6 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Apoptosis; PI3K

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PF-4989216.html

• Concentration :

  10mM

• Purity :

  99.38

• Solubility :

  DMSO : ≥ 29 mg/mL

• Smiles :

  N#CC1=C(N2CCOCC2)SC(C3=NC=NN3)=C1C4=CC=C(C#N)C=C4F

• Molecular Formula :

  C18H13FN6OS

• Molecular Weight :

  380.40

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Liu KK, et al. Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity. ACS Med Chem Lett. 2011 Sep 19;2 (11) :809-813.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PI3Kα

• CAS Number :

  [1276553-09-3]