PF-4800567

• Description:

  PF-4800567 is a potent and selective inhibitor of casein kinase 1 (CK1), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM) .

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Casein Kinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Stem Cell/Wnt

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/PF-4800567.html

• Purity:

  99.69

• Solubility:

  1 M HCl : 50 mg/mL (ultrasonic) |DMSO : 40 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)

• Smiles:

  NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1

• Molecular Formula:

  C17H18ClN5O2

• Molecular Weight:

  359.81

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Walton KM, et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330 (2) :430-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CK1

• CAS Number:

  1188296-52-7