EIF2α activator 2

• Description :

  EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM) . EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].

• UNSPSC :

  12352005

• Target :

  Eukaryotic Initiation Factor (eIF)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/eif2α-activator-2.html

• Concentration :

  10mM

• Purity :

  99.57

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  FC(F)(F)C(C=C1)=CC=C1O[C@H](CC2)CC[C@@H]2NC(NC3=CC(C(F)(F)F)=CC=C3)=O

• Molecular Formula :

  C21H20F6N2O2

• Molecular Weight :

  446.39

• References & Citations :

  [1]Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4- (aryloxy) cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EIF2

• CAS Number :

  [1501618-04-7]