PD 151746

CAT: 0804-HY-19749-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19749-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM) . IC50 value: 0.26 ± 0.03 μM (Ki, for μ-calpain), 5.33 ± 0.77 μM (Ki, for m-calpain) [1] Target: calpain in vitro: The μ-calpain inhibitor PD 151746 decreases oxLDL-induced cytotoxicity. [2]
CAS Number
[181765-30-0]
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/PD-151746.html
Concentration
10mM
Purity
95.03
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2
Molecular Formula
C11H8FNO2S
Molecular Weight
237.25
References & Citations
[1]Wang KK, et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93 (13) :6687-92.|[2]P?rn-Ares MI, et al. Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J. 2003 Sep 1;374 (Pt 2) :403-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-163844PD-1/PD-L1-IN-49
HY-163307PD-1/PD-L1-IN-39
HY-145772PD-1/PD-L1-IN-21
HY-132192-01PD-1/PD-L1-IN-9
HY-152240-01PD-1/PD-L1-IN-29
HY-160585PD-L1/PD-1-IN-1
HY-143305PD-1/PD-L1-IN-25
HY-N12537PD-1/PD-L1-IN-38
HY-163041PD-1/PD-L1-IN-36
HY-149356PD-1/PD-L1-IN-31

Alternative Products

CatalogName
563384PD-151746
C12676-01PD 151746
A14245-5PD 151746 5mg
A14245-50PD 151746 50mg
A14245-10PD 151746 10mg
A14245-25PD 151746 25mg
A14245-10mM-DPD 151746 10mM * 1mL in DMSO

Popular Products