MK-7622

• Description:

  MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs) . MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine (HY-N0296) -induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD) [1][2].

• Product Name Alternative:

  M1 receptor modulator

• UNSPSC:

  12352005

• Target:

  Calcium Channel; mAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/M1-receptor-modulator.html

• Purity:

  99.89

• Solubility:

  DMSO : 70 mg/mL (ultrasonic)

• Smiles:

  O=C1N([C@@H]2[C@@H](O)CCCC2)C=NC3=C1C=C(CC4=CC=C(C)N=C4)C5=CC=CC=C53

• Molecular Formula:

  C25H25N3O2

• Molecular Weight:

  399.48

• References & Citations:

  [1]Uslaner JM, et al. Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622. J Pharmacol Exp Ther. 2018 Jun;365 (3) :556-566. |[2]Moran SP, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43 (8) :1763-1771. |[3]Beshore DC, et al. MK-7622: A First-in-Class M1Positive Allosteric Modulator Development Candidate. ACS Med Chem Lett. 2018 Apr 30;9 (7) :652-656.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  MAChR1

• CAS Number:

  [1227923-29-6]