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MK-7622

CAT: 0804-HY-15618-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15618-01Size:5 mg
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Description
MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs). MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine -induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD)[2].
CAS Number
1227923-29-6
Product Name Alternative
M1 receptor modulator
UNSPSC
12352005
Target
Calcium Channel; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/M1-receptor-modulator.html
Purity
99.89
Solubility
DMSO : 70 mg/mL (ultrasonic)
Smiles
O=C1N([C@@H]2[C@@H](O)CCCC2)C=NC3=C1C=C(CC4=CC=C(C)N=C4)C5=CC=CC=C53
Molecular Formula
C25H25N3O2
Molecular Weight
399.48
References & Citations
[1]Uslaner JM, et al. Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622. J Pharmacol Exp Ther. 2018 Jun;365 (3) :556-566. |[2]Moran SP, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43 (8) :1763-1771. |[3]Beshore DC, et al. MK-7622: A First-in-Class M1Positive Allosteric Modulator Development Candidate. ACS Med Chem Lett. 2018 Apr 30;9 (7) :652-656.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MAChR1

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