TTT-28

CAT: 0804-HY-101511-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101511-01Size:5 mg
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Description
TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1) -mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1[1].
CAS Number
[1609138-51-3]
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ttt-28.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(C)C)C1=NC(C(NC2=CC=CC=C2C(C3=CC=CC=C3)=O)=O)=CS1)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C31H31N3O6S
Molecular Weight
573.66
References & Citations
[1]Wang YJ, et al. Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Sci Rep. 2017 Feb 9;7:42106.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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