TTT 3002

CAT: 0804-HY-111249Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-111249Size:1 Each
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Description
TTT 3002 is a potent and orally active FLT3 inhibitor. TTT 3002 potently inhibits FLT3 phosphorylation by activating mutations at residue D835, with an IC50 of 0.2 nM. TTT 3002 can be used for AML (acute myeloid leukemia) research[1].
CAS Number
[871037-95-5]
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ttt-3002.html
Solubility
10 mM in DMSO
Smiles
C[C@]12N3C4=C(C5=CC=CC=C35)C(CNC6=O)=C6C7=C4N(C8=CC=CC=C87)[C@](C[C@]2(N)C(NC)=O)([H])O1
Molecular Formula
C27H23N5O3
Molecular Weight
465.50
References & Citations
[1]Ma H, et al. TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo. Blood. 2014 Mar 6;123 (10) :1525-34
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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