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TNF-beta

CAT: 0209-102-P88Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P88Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNF-beta, also known as lymphotoxin-alpha (LTalpha) and TNF-alpha are two structurally and functionally related proteins that bind to the same cell surface receptors (TNF RI and TNF RII) and produce a vast range of similar, but not identical effects. Mature TNF-beta/LTalpha and TNF-alpha share approximately 35% protein sequence homology, and the biologically active secreted forms of both proteins are trimers. Human and mouse TNF-beta/LTalpha share approximately 74% homology in their amino acid sequence and exhibit cross-species activity. Soluble TNF-beta/LTalpha is a homotrimer in solution. Secreted TNF-beta/LTalpha also complexes with the membrane associated LTbeta/TNFSF3 to generate two types of heterotrimers, LTalpha1/beta2 and LTalpha2/beta1.
Synonyms
LTA; LT; TNFB; TNFSF1
NCBI Gene ID
4049
UniProt
P01374
Accession Number
NP_001153212.1
Accession Number mRNA
NM_001159740.1
Chromosomal Location
6p21.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human TNF-beta
Clone
Rabbit IgG
Applications
ELISA, WB, N
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

UniProtKB · P01374

Lymphotoxin-alpha

TNFB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01374
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LTA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
LT-alpha
EC number
—
Processing
Precursor
Secondary accessions
Q8N4C3, Q9UKS8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

Cytokine

PTM

Glycoprotein

Cellular component

MembraneSecreted

Domain

Signal

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