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TNF-alpha

CAT: 0209-M10-041-L500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0209-M10-041-L500Size:500 µg
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Description
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant murine TNF-α is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Synonyms
Tnf; DIF; Tnfa; TNFSF2; Tnfsf1a; TNFalpha; TNF-alpha
NCBI Gene ID
21926
UniProt
P06804
Accession Number
NP_038721.1
Accession Number mRNA
NM_013693.2
Chromosomal Location
17 B1; 17 19.06 cM
Reactivity
Mouse
Cross Reactivity
Monkey, Rat, Mouse, Human, Chicken, Cow
Sequence
MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Length
156
Form
Lyophilized
Molecular Weight
17.3 kDa
Host or Source
E. coli

UniProtKB · P06804

Tumor necrosis factor

TNFA_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P06804
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Tnf
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O35853, Q62326, Q91VF3
Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

Cellular component

Cell membraneMembraneSecreted

Molecular function

Cytokine

PTM

Disulfide bondGlycoproteinLipoproteinMyristatePhosphoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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