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TIE-2

CAT: 0209-101-M50Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M50Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF) -like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse) /-4 (human) . Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.
Synonyms
TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B
NCBI Gene ID
7010
UniProt
Q02763
Accession Number
NP_000450.2
Accession Number mRNA
NM_000459.3
Chromosomal Location
9p21
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human soluble extracellular TIE-2
Clone
(#tek2)
Applications
ELISA, WB, FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
ELISA: Use at 1-2 µg/ml. Western blotting: Use at 2-5 µg/ml. FACS analysis: Use at 2-5 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Notes
The monoclonal antibody will detect native human TIE-2/tek in ELISA experiments and on the surface of different human cell types. The antibody can be used for ELISA experiments, Western blotting, FACS and cell sorting.
Host or Source
Mouse
Isotype
IgG1

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