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TIE-1

CAT: 0209-101-MBi48Size: 50 µgDry Ice: NoHazardous: No
CAT#: 101-MBi48Size: 50 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF) -like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse) /-4 (human) . Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.
Synonyms
TIE1; TIE; JTK14
NCBI Gene ID
7075
UniProt
P35590
Accession Number
NP_005415
Accession Number mRNA
NM_005424
Chromosomal Location
1p34-p33
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human soluble extracellular TIE-1
Clone
(#6F12)
Label
Biotin
Applications
ELISA
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
ELISA: Use at 1-15 µg/ml.
Form
Lyophilized
Buffer
PBS
Additives
BSA (50x), 0.02% sodium azide
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Notes
The unconjugated antibody will detect native human TIE-1 in ELISA experiments and on the surface of different human cell types. The antibody can be used for ELISA experiments and Western blotting.
Host or Source
Mouse
Isotype
IgG1

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Alternative Products

CatalogName
337205-01Tie-1
226326-01Tie-1 (Tyrosine-Protein Kinase Receptor Tie-1, TIE1, TIE) discontinued
042827Tie1, ID (Tie1, Tie, Tie-1, Tyrosine-protein kinase receptor Tie-1)
MBS6000832-01Tie1, ID (Tie1, Tie, Tie-1, Tyrosine-protein kinase receptor Tie-1)
346249-01Tie-1 discontinued
E80805-2TIE-1 Antibody
MBS8564658-01TIE-1 Antibody
MBS856931-01TIE-1 Antibody
GWB-7C7BBCTie-1, Antibody
C19314-01Tie-1 Antibody

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