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RBP-4

CAT: 0209-101-M826Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M826Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol) . RBP4 has a molecular weight of approximately 21 kDa and is encoded by the RBP4 gene in humans. It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream as a hepatokine bound to retinol in a complex with transthyretin. RBP4 has been a drug target for ophthalmology research due to its role in vision. RBP4 may also be involved in metabolic diseases as suggested by recent studies. The protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply to the epidermal cells.
Synonyms
Interstitial; Plasma retinol-binding protein; RBP4; retinol binding protein 4, plasma; RetinolBinding Protein 4; retinol-binding protein 4, plasma
NCBI Gene ID
5950
UniProt
P02753
Accession Number
NP_001310446.1
Accession Number mRNA
NM_001323517.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human RBP-4
Clone
(#30E12)
Applications
E
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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