BMP-4

• Description:

  Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.

• Synonyms:

  BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6

• NCBI Gene ID:

  652

• UniProt:

  P12644

• Accession Number:

  NP_001193

• Accession Number mRNA:

  NM_001202

• Chromosomal Location:

  14q22-q23

• Reactivity:

  Human

• Cross Reactivity:

  Human, Mouse, Rat

• Sequence:

  SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.

• Purity:

  >95% by SDS-PAGE

• Bioactivity:

  The ED50, as calculated by Alkaline phosphatase activity induced in ATDC-5 cells is 15ng/ml corresponding to a specific activity which is 6.7 x 10^4 units/mg.

• Length:

  116

• Form:

  Lyophilized

• Buffer:

  2XS PBS + 6% EtOH

• Reconstitution:

  2XS PBS + 6% EtOH

• Molecular Weight:

  26,2 kDa

• Host or Source:

  CHO cells