NT-4

• Description:

  NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues) .

• Synonyms:

  NTF4; NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5

• NCBI Gene ID:

  4909

• UniProt:

  P34130

• Accession Number:

  NP_006170.1

• Accession Number mRNA:

  NM_006179.4

• Chromosomal Location:

  19q13.3

• Reactivity:

  Human

• Cross Reactivity:

  Rat, Frog, Human, Mouse

• Sequence:

  GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

• Length:

  130

• Form:

  Lyophilized

• Molecular Weight:

  14 kDa

• Host or Source:

  E. coli