PF-4 (CXCL4)

• Description:

  PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

• Synonyms:

  PF4; PF-4; CXCL4; SCYB4

• NCBI Gene ID:

  5196

• UniProt:

  P02776

• Accession Number:

  NP_002610.1

• Accession Number mRNA:

  NM_002619.2

• Chromosomal Location:

  4q12-q21

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Trout, Human, Bacteria

• Sequence:

  EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.

• Length:

  70

• Form:

  Lyophilized

• Molecular Weight:

  7.8 kDa

• Host or Source:

  E. coli