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PDGFR-alpha

CAT: 0209-101-M824Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M824Size:100 µg
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Description
PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulfidelinked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Whereas PDGF Rα binds all three PDGF isoforms with high affinity, PDGF Rβ binds PDG-FBB and AB, but not PDGFAA. Both PDGF Rα and PDGF Rβ are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for MCSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the α and β receptors is independently regulated in various cell types. Only PDGF Rα is expressed in oligodendrocyte progenitor cells, mesothelial cell and liver endothelial cells. Soluble PDGFRα has been detected in cell conditioned medium and human plasma. Recombinant soluble PDGF Rα binds PDGF with high affinity and is a potent PDGF antagonist.
Synonyms
PDGFRA; CD140A; PDGFR2; PDGFR-2; RHEPDGFRA
NCBI Gene ID
5156
UniProt
P16234
Accession Number
NP_006197.1
Accession Number mRNA
NM_006206
Chromosomal Location
4q12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
N-terminal recombinant human PDGFR alpha fragment
Clone
(#8A12)
Applications
IP, FC
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

UniProtKB · P16234

Platelet-derived growth factor receptor alpha

PGFRA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16234
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDGFRA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PDGF-R-alpha, PDGFR-alpha
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B2RE69, E9PBH0, Q6P4H5, Q96KZ7, Q9UD28
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionGolgi apparatusMembrane

Biological process

ChemotaxisHost-virus interaction

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variantProto-oncogene

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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