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Alpha FAP

CAT: 0209-101-M103Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M103Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FAP is a 760 amino acid long type II transmembrane glycoprotein. It contains a very short cytoplasmic N terminal part (6 amino acids), a transmembrane region (amino acids 7–26), and a large extracellular part with an alpha/beta-hydrolase domain and an eight-bladed beta-propeller domain.[9][10] A soluble form of FAP, which lacks the intracellular and transmembrane part, is present in blood plasma.[11] FAP is a non-classical serine protease, which belongs to the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9.[12] FAP is most closely related to DPPIV (approximately 50% of their amino acids are identical) . The active site of FAP is localized in the extracellular part of the protein and contains a catalytic triad composed of Ser624 Asp702 His734 in humans and mice.[10] FAP is catalytically active as a 170kD homodimer and has a dipeptidase and an endopeptidase activity.
Synonyms
Fibroblast activation protein alpha, Prolyl endopeptidase FAP, Integral membrane serine protease
NCBI Gene ID
2191
UniProt
Q12884
Accession Number
NP-001278736.1
Accession Number mRNA
NM_001291807.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human alphaFAP
Clone
(#16F50)
Applications
FC, E
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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