M-CSF Recombinant Protein

M-CSF Recombinant Protein

• Description: Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Macrophage Colony Stimulating Factor Human Recombinant produced in E. coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 36.8 KD. M-CSF is purified by proprietary chromatographic techniques.
• Synonyms: CSF1; MCSF; CSF-1
• CAS Number: 9000-83-3
• NCBI Gene ID: 1435
• UniProt: P09603
• Accession Number: NP_000748.3
• Accession Number mRNA: NM_000757
• Gene Location: 1p21-p13
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Monkey, Mouse, Rat, Human
• Sequence: MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS
• Detection Range: The biological activity was determined by the dose-dependent induction of proliferation in NFS60 cells (Murine myeloid Leukemia cell line).
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 95% by SDS-PAGE
• Length: 159
• Form: Lyophilized
• Buffer: PBS
• Molecular Weight: 36.8 kDa
• Shipping Conditions: Room Temperature