M-CSF Recombinant Protein

• Background:

  M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant human M-CSF is a 36.8 kDa homodimeric protein containing two 159 amino acid polypeptide subunits.

• NCBI Gene ID:

  1435

• Swiss Prot:

  P09603

• Accession Number:

  NP_000748.3

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Growth Factors, Immunology, Signal Transduction

• Purity:

  Greater than 98% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized M-CSF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted M-CSF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing M-CSF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Colony stimulating factor 1 (macrophage)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  MCSF, CSF-1, Macrophage colony-stimulating factor 1, Lanimostim

• Species:

  Human

• Protein ID:

  27262661

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3