M-CSF Recombinant Protein

• Description:

  Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Macrophage Colony Stimulating Factor Human Recombinant produced in E. coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 36.8 KD. M-CSF is purified by proprietary chromatographic techniques.

• Synonyms:

  CSF1; MCSF; CSF-1

• NCBI Gene ID:

  1435

• UniProt:

  P09603

• Accession Number:

  NP_000748.3

• Accession Number mRNA:

  NM_000757

• Gene Location:

  1p21-p13

• Host:

  E. coli

• Origin Species:

  Human

• Species Reactivity:

  Monkey, Mouse, Rat, Human

• Sequence:

  MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

• Detection Range:

  The biological activity was determined by the dose-dependent induction of proliferation in NFS60 cells (Murine myeloid Leukemia cell line).

• Endotoxin:

  < 0.1 ng/µg of protein (<1EU/µg)

• Purity:

  > 95% by SDS-PAGE

• Length:

  159

• Form:

  Lyophilized

• Buffer:

  PBS

• Molecular Weight:

  36.8 kDa

• Shipping Conditions:

  Room Temperature

• N Terminal Sequence:

  MEEVS

• CAS Number:

  9000-83-3